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A five-product topical regimen may provide patients with facial photodamage and hyperpigmentation with an effective, comprehensive treatment, according to study results presented at the American Academy of Dermatology Summer Meeting.

In a single-center, 24-week study, researchers assessed the efficacy and tolerance of a five-product regimen known as GRASS in 72 patients with Fitzpatrick Skin types I to IV.

The regimen included physiologically balanced growth factors, retinol, antioxidants, a multimodal skin brightener and sunscreen. Tolerability and efficacy were assessed at baseline and at weeks 4, 8, 12, 18 and 24.

From baseline to week 12, overall hyperpigmentation improved by more than 15%; photodamage improved by 13% and fine lines improved by close to 22%, according to the researchers.

By week 24, patients had mild-to-moderate improvement in overall hyperpigmentation and mild-to-moderate improvement in overall photodamage.

In a subject questionnaire, 100% of patients agreed that the system improved the evenness of their skin tone, according to the researchers.

Reference: Makino ET. Poster #114. Presented at: the American Academy of Dermatology Summer Meeting; August 6-10, 2014; Chicago, IL.

Disclosure: The study and poster were supported by a grant from SkinMedica, an Allergan company.


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